Patient Characteristics, Associated Factors, and Clinical Outcomes of Prescribing Encorafenib and Binimetenib Versus Dabrafenib and Trametinib Among BRAF v600 Mutated Metastatic Melanoma Patients
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About
This was a retrospective real-world evidence cohort study. The study was conducted using the NOBLE (Novartis Braf+ meLanoma patients ObsErvational) dataset, with a study period from 01 January 2011 to 31 May 2020. All included patients were ≥18 years of age and were required to have a diagnosis of unresectable stage III or IV melanoma (ICD-9 172.x & ICD-10 C43 or D03x), treatment with dabrafenib and trametinib (dab/tram) or encorafenib and binimetenib (enco/bini) on or after 01 June 2018, and evidence of a BRAF-positive result prior to or up to 30 days after therapy initiation.
No quota of centers was established a priori. Given the retrospective nature of this study, all patients who met the inclusion/exclusion criteria from the NOBLE dataset were included.
Enrollment
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Volunteers
Inclusion and exclusion criteria
Inclusion criteria
- Diagnosis of melanoma (ICD-9 172.x & ICD-10 C43 or D03x)
- Pathologic stage III (unresectable) or IV at initial diagnosis on or after 01 January 2011
- 1L treatment with enco/bini or dab/tram on or after 01 June 2018
- Evidence of a BRAF test
- Evidence of a BRAF-positive result prior to or up to 30 days after 1L therapy initiation
- At least 18 years of age at the time of initiation of 1L treatment Exclusion criteria
- Documented receipt of a clinical trial treatment for cancer at any time on or after September 2015
- Diagnosis of a second primary cancer or secondary cancer following initiation of 1L metastatic melanoma (MM) treatment
Trial design
214 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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