Patient Morbidity After Palatal Free Gingival Grafts With or Without PRF Membranes Coverage

Azienda Ospedaliera San Paolo

Status: Completed

Conditions: Postoperative Complications; Postoperative Pain; Gingival Recession

Treatments: Drug: hemostatic agents with oxidized and regenerated cellulosa; Biological: Platelet rich fibrin ( PRF)

Study type: Interventional

Funder types: Other

Identifiers

NCT03685396

PRF

Details and patient eligibility

About

This study evaluates postoperative morbidity of patients that undergo free gingival graft harvesting from palate with or without use of autogenous PRF (Platelet Rich Fibrin) membranes to cover the donor site.In the Test Group venous blood sampling was done in order to prepare PRF membranes used to cover the donor site, whereas in Control Group hemostatic agents with oxidized and regenerated cellulosa were used.

Enrollment: 42 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• FMPS (Full Mouth Plaque Score) and FMBS (Full Mouth Bleeding Score) < 20%,
• presence of two adjacent Miller's Class I and II recession defects on natural teeth (≥ 2mm in depth);

Exclusion criteria

• contraindications for periodontal surgery
• taking medications or having diseases known to interfere with periodontal tissue health or healing and coagulation.
• smoking more than 10 cigarettes a day
• Gingival recessions on molar teeth were excluded.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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42 participants in 2 patient groups

Test Group

Experimental group

Description:

In the Test Group venous blood sampling was done in order to prepare PRF membranes used to cover the donor site of the connective tissue graft.

Treatment:

Biological: Platelet rich fibrin ( PRF)

Control Group

Active Comparator group

Description:

In Control Group hemostatic agents with oxidized and regenerated cellulosa were used to cover the donor site.

Treatment:

Drug: hemostatic agents with oxidized and regenerated cellulosa