Patient Navigation and the Planning Advance Care Together Website to Improve Goals of Care Conversations in Hematopoietic Cell Transplant Survivors, IMPACT-HCT Trial

Fred Hutchinson Cancer Center (FHCC)

Status: Enrolling

Conditions: Hematopoietic and Lymphatic System Neoplasm

Treatments: Other: Best Practice; Other: Internet-Based Intervention; Behavioral: Patient Navigation; Other: Survey Administration

Study type: Interventional

Funder types: Other

Identifiers

NCT07052630

RG1125595

NCI-2025-04134 (Registry Identifier)

20855

Details and patient eligibility

About

This clinical trial evaluates the impact of patient navigation and the Planning Advance Care Together (PACT) website, either alone or in combination with one another, on advanced care planning (ACP) in patients with blood cancers who received a hematopoietic cell transplant (HCT). Engagement in ACP, including having goals of care conversations, improves quality of care at the end of life and supporting this should be included in all cancer survivorship care. Patient navigation is a healthcare service that is designed to guide a patient through the healthcare system and reduce barriers to timely screening follow-up, diagnosis, treatment, and supportive care. PACT is a web-based tool that provides information about ACP, assistance with documents for advanced directives, a supportive network and a forum for discussions about ACP. Patients who engage in ACP are more likely to have higher quality of life at the end of life, receive the care they want, die where they prefer, utilize hospice effectively, and are less likely to receive futile, aggressive care at the end of life. For HCT survivors at ongoing risk of death and other disease-related complications, having a plan in place for care they want is critical. Patient navigation and/or the PACT website may improve ACP, including completion of advance care directives and goals of care conversations, in patients with blood cancers who received an HCT.

Full description

OUTLINE: Patients are randomized to 1 of 4 conditions.

CONDITION 1 (PACT + PATIENT NAVIGATION): Patients interact with the PACT website over 4 weeks and receive a navigation session over 30-45 minutes with a trained health coach to review ACP.

CONDITION 2 (PATIENT NAVIGATION ONLY): Patients receive a navigation session over 30-45 minutes with a trained health coach to review ACP.

CONDITION 3 (PACT ONLY): Patients interact with the PACT website over 4 weeks.

CONDITION 4 (NO PACT/NO PATIENT NAVIGATION): Patients receive standard/usual care for 4 weeks on study.

After completion of study intervention, patients are followed up at 4 and 12 weeks.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Received a transplant for a hematologic malignancy
• Current age 18 years of age or older
• Currently 1 to 5 years after HCT
• Ability to speak and read English
• Has not completed all advance directives and/or had a goals of care (GOC) conversation with their physician
• Access to the internet (via computer, tablet, or mobile device)

Exclusion criteria

• Unable to provide informed consent
• Uncontrolled psychiatric conditions (confirmed through electronic health record [EHR] by study staff)

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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40 participants in 4 patient groups

Condition 1 (PACT, patient navigation)

Experimental group

Description:

Patients interact with the PACT website over 4 weeks and receive a navigation session over 30-45 minutes with a trained health coach to review ACP.

Treatment:

Other: Survey Administration

Behavioral: Patient Navigation

Other: Internet-Based Intervention

Condition 2 (patient navigation)

Experimental group

Description:

Patients receive a navigation session over 30-45 minutes with a trained health coach to review ACP.

Treatment:

Other: Survey Administration

Behavioral: Patient Navigation

Condition 3 (PACT)

Experimental group

Description:

Patients interact with the PACT website over 4 weeks.

Treatment:

Other: Survey Administration

Other: Internet-Based Intervention

Condition 4 (standard/usual care)

Active Comparator group

Description:

Patients receive standard/usual care for 4 weeks on study.

Treatment:

Other: Survey Administration

Other: Best Practice