Patient Registry of Posner-Schlossman Syndrome

Peking University

Status: Enrolling

Conditions: Posner Schlossman Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT03233477

IRB00006761-2014166

Details and patient eligibility

About

Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a condition characterized by recurrent, acute attacks of mild, nongranulomatous, anterior uveitis accompanied by markedly elevated intraocular pressure. Most of patients are the 20 to 50-year-old young adults, with unilateral eye involvement. PSS was originally deemed benign, but is now recognized as a relatively rare cause of chronic secondary glaucoma,especially in patients with recurrent episodes. This relatively rare disease is likely the result of the infections of a variety of organisms, and the bulk of literature supports the cytomegalovirus (CMV) as the leading cause.

This study is an observational study that does not interfere with the normal clinical diagnosis and treatment process. The investigators in this study focus on observing the clinical symptoms and outcome of PSS, analyzing the factors that affect the prognosis of PSS, studying the association of its pathogenesis with the psychological status and the behavioral types of PSS patients; exploring the relationship between infection (CMV, HSV, Hp) and PSS; and studying the changes of local and systemic cytokine expression and its significance in patients with PSS.

Enrollment: 180 estimated patients

Sex: All

Ages: 12 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Volunteer to take part in this study and sign informed consent by oneself or the patient's legal representative
• Clinical diagnosis of Posner-Schlossman Syndrome, age-related cataract, or primary open-angle glaucoma
• Live in Beijing, China or being able to visit the Peking University Third Hospital every year after the beginning of the study or whenever the disease relapses

Exclusion criteria

• Fit any exclusion criteria of the patient's group

Trial design

180 participants in 3 patient groups

Posner-Schlossman Syndrome

Description:

Inclusion criteria： * Clinical diagnosis of Posner-Schlossman Syndrome * Able to communicate with doctor and understand this study Exclusion criteria: * Not be able to communicate with doctor and understand this study * One or more authorized investigators think he or she will suffer from any severe risks from the study

cataract

Description:

Inclusion criteria： * Clinical diagnosis of age-related cataract * Prepare for cataract operation * Open angle and intraocular pressure is normally at anytime * No family history of glaucoma Exclusion criteria: * Patients above 65 years old * With Secondary ocular hypertension * Have the history of receiving any ophthalmologic operation or anti-viral therapy * With diabetes mellitus * With autoimmune disease * Be receiving any therapy that can influence the virus-infection state and biochemical characteristics of serum and aqueous humor, or have received such therapy before one month

primary open-angle glaucoma

Description:

Inclusion criteria： * Both eyes involved * Open angle * Progressive glaucomatous optic neuropathy * Specific visual field loss of glaucoma * Intraocular pressure above the up limit of normal people Exclusion criteria: * Patients above 65 years old * With Secondary ocular hypertension * Have the history of receiving any ophthalmologic operation or anti-viral therapy * With diabetes mellitus * With autoimmune disease * Be receiving any therapy that can influence the virus-infection state and biochemical characteristics of serum and aqueous humor, or have received such therapy before one month