Patient Satisfaction and Long-term Safety of Intravesical Aminoglycoside Instillations in UTI Prevention (INSTILMENT)

Leiden University Medical Center (LUMC)

Status: Completed

Conditions: Urinary Tract Infections; Recurrent Urinary Tract Infection

Treatments: Drug: Intravesical aminoglycoside instillations

Study type: Observational

Funder types: Other

Identifiers

NCT05376670

nWMODIV2_2022013

Details and patient eligibility

About

Antimicrobial prophylactic treatment of recurrent UTI is limited by emerging resistance, antibiotic allergies and intolerances. Intravesical aminoglycoside instillations (IAI) have been shown to reduce recurrence rate, without a short-term decline in kidney function or hearing. Thus far, treatment satisfaction has not yet been assessed, while this may play an important role in treatment adherence and persistence. Moreover, there is no data on the long-term safety of IAI, e.g. regarding the development of (pre)malignant bladder lesions.

Enrollment: 44 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Currently receiving or having received (no minimal duration) continuous or post-coital IAI (gentamicin, tobramycin or amikacin) for recurrent UTI prophylaxis and treatment

Exclusion criteria

• Exclusively receiving IAI for 'on-demand' treatment of UTI and not prophylactic purposes
• Receiving IAI as suppressive therapy for chronic prostatitis
• Presence of a chronic indwelling catheter
• Patient has objected to the use of his/her data
• Inability to provide informed consent