Patientheque in Patients With a Psychosis . (LONGIPEP)

Regional University Hospital Center (CHRU)

Status: Enrolling

Conditions: Schizophrenia; Schizophrenia, Childhood; Schizophrenia Prodromal

Treatments: Other: Blood samples (36 mL) + fecal samples + hair sample

Study type: Interventional

Funder types: Other

Identifiers

NCT05340348

29BRC20.0097

Details and patient eligibility

About

Establishment of a patient library for patients who have had a first psychotic episode and who have an "at risk" status for psychotic disorder (GRD, APS, BLIPS group) or a psychosis threshold during CAARMS administration. Samples are taken on inclusion, at 2 years, and if relapse or significant clinical event within 5 years of inclusion, on 250 patients for 10 years.

Full description

The constitution of this patient library will include results of clinical tests carried out in current practice, neurocognitive tests, blood samples, audio recordings, clinical follow-up, urine samples, fecal samples, brain imaging, EEG.

Enrollment: 250 estimated patients

Sex: All

Ages: 15 to 30 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major and or minor aged 15 to 30 assessed within the CEVUP (Consultation for the Assessment of Psychological Vulnerability) and cared for at the psychiatry center as part of a first psychotic episode (Diagnosis CIM 10: F20 -F29 first hospitalization). These patients are referred by care and medico-social partners (general practitioners, school doctors, school nurses, educators, addictologists, psychiatrists
• "At risk" status for psychotic disorder (GRD, APS, BLIPS group) or psychosis threshold during the CAARMS test (psychometric scale for the assessment of psychotic symptoms)
• Consent of the patient or his legal guardian

Exclusion criteria

• History of psychosis for more than one year
• "Not at risk" status for psychotic disorder on the CAARMS (psychometric scale for the assessment of psychotic symptomatology)
• IQ<70 (WAIS)
• Neurological disorder or other health problem that may explain the disorders
• Refusal to participate - History of psychosis for more than one year

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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250 participants in 1 patient group

Patient library

Other group

Description:

All the patients are included in one arm. They will undergo various type of samples.

Treatment:

Other: Blood samples (36 mL) + fecal samples + hair sample