Patients' Outcome With Severe or Fulminant Hepatic Insufficiency, Hospitalized in the Public Hospitals of Paris (DEVINHEF)

Assistance Publique - Hôpitaux de Paris

Status: Unknown

Conditions: Fulminating Hepatic Failure

Study type: Observational

Funder types: Other

Identifiers

NCT04658407

AP-HP200240

Details and patient eligibility

About

The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe, fulminating acute liver failure in the public hospitals of paris.

Full description

Severe, fulminating acute liver failure is a rare but serious disease. The overall prognosis has improved in recent years thanks to advances in medical management and liver transplantation.

However, the epidemiology of this disease in France, the survival with or without liver transplantation of these patients and the factors that can influence this survival are not well known.

The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe, fulminating acute liver failure in the public hospitals of paris (APHP).

The data will come from the APHP Health Data Warehouse

Enrollment: 18,000 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 15
• Severe liver failure or toxicants that may cause a liver failure Or
• (PR<50% or INR >1.5) And ALT >250

Exclusion criteria

• Patients with underlying chronic liver disease
• Patients with the conditions given by this following ICD (International Classification of Diseases) : B18 - E831 - K70 - K715 - K717 - K730- K731 - K732 - 738 - K74 - K753 - K758 - K760 - K761

Trial design

18,000 participants in 1 patient group

all patients diagnosed with a severe hepatic failure

Description:

Retrospective cohort using only data already entered in the Health data warehouse of the APHP (Public Paris Hospital)