Patient's Pretreatment Expectations About Post-Lyme Symptoms

University Medical Centre Ljubljana

Status: Enrolling

Conditions: Erythema Migrans

Treatments: Drug: Antibiotics (preferentially oral doxycycline 100 mg bid)

Study type: Interventional

Funder types: Other

Identifiers

NCT03462329

Pretreatment expectations

Details and patient eligibility

About

The investigators will focus on pretreatment expectations of patients with early Lyme disease manifested as erythema migrans with the aim of assessing the association between pretreatment expectations quantified with a questionnaire and treatment outcome quantified with the presence of post-Lyme symptoms. Furthermore, the investigators will compare the prevalence of nonspecific symptoms among patients and among age-matched controls without a history of Lyme borreliosis.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• erythema migrans

Exclusion criteria

• pregnancy or lactation
• immunocompromised
• taking antibiotic with antiborrelial activity within 10 days

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

patients with erythema migrans

Active Comparator group

Description:

Patients will be treated with antibiotics for Lyme disease.

Treatment:

Drug: Antibiotics (preferentially oral doxycycline 100 mg bid)

controls

No Intervention group

Description:

Control subjects will not be given antibiotics.