Patients With Asymptomatic Hyperuricemia Have Stronger Local Inflammatory Response and Worse Outcome After Total Knee Arthroplasty

Zhejiang University

Status: Not yet enrolling

Conditions: Arthritis Knee

Study type: Observational

Funder types: Other

Identifiers

NCT05476367

2021-0785

Details and patient eligibility

About

We identify all patients who had undergone primary total knee arthroplsty(TKA) from April 1, 2015, to March 30, 2016. Patients are grouped by uric acid level. The knee society score(KSS score) and the hospital for special surgery knee score (HSS score) before the surgery and 6 years after the surgery will be collected. Also the clinical data will be collected.

Enrollment: 614 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients who had undergone primary TKA from April 1, 2015, to March 30, 2016

Exclusion criteria

• (1) infection, (2) rheumatoid arthritis, (3) ankylosing spondylitis, (4) revision surgery, (5) patients with unicondylar knee replacement, (6) patients who have been diagnosed with gout or previous gouty symptoms, and (7) patients combined with preoperative redness or swelling.

Trial design

614 participants in 2 patient groups

patients with normal uric acid level

Description:

The uric acid level is below 420 μmol/L in men and 360 μmol/L in women

patients with high uric acid level

Description:

The uric acid level is higher than 420 μmol/L in men and 360 μmol/L in women.