Patogenic Mutation in 5 Genes

Dr Cipto Mangunkusumo General Hospital

Status: Completed

Conditions: PIK3CA Gene Mutation; KRAS Mutation-Related Tumors; APC Gene Mutation; MLH1 Gene Mutation; TP53 Gene Mutation; Colorectal Cancer

Treatments: Other: co-occuring mutation

Study type: Observational

Funder types: Other

Identifiers

NCT04976439

MUTASICRC

Details and patient eligibility

About

This is a pathogenic mutation profile of colorectal patients specifically in 5 genes, i.e. APC, TP53, PIK3CA, KRAS, and MLH1. Single nucleotide variants identified were synchronized with patients' characteristics.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• FFPE samples fullfilling purity criterion and pass quality control

Exclusion criteria

• none

Trial design

22 participants in 5 patient groups

Age

Treatment:

Other: co-occuring mutation

Grade

Treatment:

Other: co-occuring mutation

Tumor location

Treatment:

Other: co-occuring mutation

Stage

Treatment:

Other: co-occuring mutation

Lymphovascular invasion

Treatment:

Other: co-occuring mutation