Pattern and Short Term Outcomes of Renal Affection in Patients With Liver Cirrhosis in Al-Rajhi Liver Hospital

Assiut University

Status: Not yet enrolling

Conditions: Liver Cirrhosis

Treatments: Other: observation of renal affection in patients with liver cirrhosis

Study type: Observational

Funder types: Other

Identifiers

NCT06924294

liver cirrhosis

Details and patient eligibility

About

• To characterize the pattern and the prevalence of renal affection among liver cirrhosis patients.
• To evaluate the short-term outcomes of those patients.

Full description

Liver cirrhosis is a chronic liver disease characterized by significant scarring and dysfunction. One of its common complications is renal affection , which can significantly impact patient outcomes .

Aetiology of AKI can be categorized into three main types. These are prerenal (results from decreased renal perfusion), intrinsic renal (acute tubular necrosis), and postrenal AKI. In patients on admission, acute tubular necrosis is a common type of intrinsic AKI .

The development of portal hypertension in patients with liver cirrhosis leading to a reduction in systemic vascular resistance as a result of primary arterial vasodilation in the splanchnic circulation is the primary cause of AKI in cirrhotics. This mechanism primarily leads to hepatorenal syndrome. In addition, the underlying causes of liver cirrhosis can be the cause of intrinsic renal disease .

Early identification and management of AKI may improve outcomes. AKI in patients with liver cirrhosis in Egypt and their impact on inpatient mortality are largely unknown. This study was aimed at determining the prevalence, precipitating factors, predictors, and in-hospital mortality of AKI in patients with liver cirrhosis admitted at Al-Rajhi liver hospital at Egypt .

Enrollment: 290 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with liver cirrhosis admitted to the department .

Exclusion criteria

1. Patients with known preexisting chronic kidney disease according to KDIGO and EASL 2018 definitions ( defined as functional GFR <60 ml/min per 1.73 m 2 for ≥3 months or structural kidney damage for ≥3 months ).
2. Patient refusal to give informed consent ( or his first degree relatives in case of disturbed conscious level).

Trial design

290 participants in 1 patient group

liver cirrhosis admitted to Al-Rajhi liver hospital

Description:

observation of renal affection in patients known to have liver cirrhosis

Treatment:

Other: observation of renal affection in patients with liver cirrhosis