Pattern of Intestinal Parasitic Infection Among Cirrhotic Patients in Sohag University Hospital

Sohag University

Status: Not yet enrolling

Conditions: Liver Cirrhosis

Treatments: Diagnostic Test: stool analysis

Study type: Interventional

Funder types: Other

Identifiers

NCT05856721

Soh-Med-23-04-13MS

Details and patient eligibility

About

Chronic hepatic illness is one of the most serious health issues . Liver cirrhosis as the latest phase of chronic liver disease causes a disorder called cirrhosis-associated immune dysfunction syndrome (CAIDS) . Cirrhosis comes to be a systemic disease, with several organ disorders. At this phase, patients become highly vulnerable to various infections because of CAIDS, which comprises both innate and adaptive immunity). Patients with hepatic cirrhosis and ascites are more liable to other complications of liver disease, including hyponatremia, refractory ascites, or hepatorenal syndrome (HRS) . Liver cirrhotic patients are considered to be as immunosuppressed and are vulnerable to a different species of entero-parasites .

Intestinal parasitic diseases have been reported in association with diabetes mellitus (DM) which is considered a predisposing factor to infection in cirrhotic patients . Immunosuppression among DM cases is due to increased blood glucose levels, which modifies several immune responses and this renders the body susceptible to various opportunistic infections comprising parasitic infections

Intestinal parasites such as Blastocystis hominis, Cryptosporidium spp., Isospora belli, Cyclospora cayetanensis, and Microsporidia have appeared as significant opportunistic parasites that are responsible for severe illness in immunocompromised patients , subsequently, patients suffer from severe morbidity and high mortality).

Enrollment: 200 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed to have liver cirrhosis with or without hepatocellular carcinoma.

Exclusion criteria

• . Cirrhotic patients with renal impairment.
• . Cirrhotic patients with cardiac diseases.

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

cases group

Active Comparator group

Description:

One hundred patients with liver cirrhosis and GIT complaints

Treatment:

Diagnostic Test: stool analysis

control group

Active Comparator group

Description:

One hundred patients with GIT complaints but not have any cormobidity

Treatment:

Diagnostic Test: stool analysis