Patterns of Neurodevelopmental Disorders

Richard Frye

Status: Enrolling

Conditions: Mitochondrial Encephalomyopathies; Pediatric Acute-Onset Neuropsychiatric Syndrome; Cerebral Folate Deficiency; Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection; Epilepsy; Autism Spectrum Disorder; Down Syndrome; Neurodevelopmental Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT06213090

NeuroClinical

Details and patient eligibility

About

The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.

Full description

Although neurodevelopmental disorders are very prevalent (for example Autism affects 1 out of every 36 children and dyslexia affects up to 15% of the population), the etiology of such disorders is not known. The purpose of this investigation is to identify common etiologies of neurodevelopmental disorders (i.e., speech delay, global developmental delay, autism) and determine if it is possible to find early indicators of the diagnosis and foster the potential for a better prognosis of these disorders. At this time the investigators examine patients with neurodevelopment disorders with various medical investigations, but the results of these investigations are not systematically evaluated. One of the goals of this research is to systematically examine this information in order to identify patterns of test abnormalities that have not been previously described. Another goal of this research is to identify the common etiologies typically identified by the medical evaluation, so we can further refine our approach. In addition, the investigators now have the ability to evaluate biological samples for biomarkers that have potential to be diagnostically useful.

Enrollment: 1,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Neurodevelopmental delays Clinical visit at an Rossignol Medical Center

Exclusion criteria

Trial design

1,000 participants in 10 patient groups

Autism

Description:

Children with autism will be followed in regards to their clinical management.

Mitochondrial Encephalopathy

Description:

Children with Mitochondrial Encephalopathy will be followed in regards to their clinical management.

Down Syndrome

Description:

Children with Down Syndrome will be followed in regards to their clinical management.

Cerebral Folate Deficiency

Description:

Children with Cerebral Folate Deficiency will be followed in regards to their clinical management.

PANS

Description:

Children with PANS will be followed in regards to their clinical management.

PANDAS

Description:

Children with PANDAS will be followed in regards to their clinical management.

Epilepsy

Description:

Children with Epilepsy will be followed in regards to their clinical management.

ADHD

Description:

Children with ADHD will be followed in regards to their clinical management.

Dyslexia and other learning disabilities

Description:

Children with Dyslexia and other learning disabilities will be followed in regards to their clinical management.

Other Neurodevelopmental Disorders

Description:

Children with Other Neurodevelopmental Disorders will be followed in regards to their clinical management.