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A growing body of literature supports the role of angiogenesis in the development and spread of a variety of human cancers including prostate cancer.
Pazopanib is a potent multi-target receptor tyrosine kinase inhibitor of vascular endothelial growth factor receptors.
Full description
VEGF expression is low in all normal prostate tissue, but markedly increased in tumor tissue, and has a positive association with MVD (micro vessel density) tumor stage, grade, and disease-specific survival in patients with prostate cancer. VEGF is known to be under the influence of HIF-1α, which is also up-regulated in the majority of prostate cancer tissue. It has been shown that complete androgen blockade down-regulates VEGF expression via the HIF-1α pathway with concomitant up-regulation of thrombospondin and induction of endothelial cell apoptosis. The VEGF pathway appears to be the dominant vascular formation pathway in prostate cancer with bFGF having a lesser role.
Pazopanib , a hydrochloride salt, is a small molecule inhibitor of several tyrosine kinases, ie: VEGF 1, 2, 3, c-KIT and platelet-derived growth factor receptors. The broad blockade of the VEGF receptors should interfere with the VEGF/VEGF-receptor pathway, and have an impact on cell growth.
According to the NCCN guidelines , first line therapy for metastatic prostate cancer is considered total androgen blockade, either utilizing orchiectomy and/or LH/RH agonists plus Casodex.
Second line therapy would depend on the patient's response to first line therapy, urgency of a response, and the location of metastatic disease.
Pazopanib has been explored in several settings. It has recently been looked at with Bicalutamide in hormone refractory prostate cancer. The second study was with earlier disease, i.e. D-0 relapse androgen-sensitive patients. The University of Chicago has a study looking at the sub-population of prostate cancer patients that have a "chemical relapse" in which patients are given one shot of Lupron, and if the PSA is adequately suppressed, the patients are randomized between pazopanib and placebo.
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Inclusion criteria
Diagnosis of adenocarcinoma of the prostate histology, currently on total androgen blockage with a bicalutamide.
Subjects must provide written informed consent prior to administration of pazopanib or the performance of any study-specific procedures or assessments, and must be willing to comply with treatment and follow up. Procedures conducted as part of the subject's routine clinical management (e.g., blood count, imaging study) and obtained prior to signing of informed consent may be utilized for screening or baseline purposes provided these procedures are conducted as specified in the protocol. Note: It is not necessary that informed consent be obtained within the protocol-specified screening window.
Received no prior second line hormone therapy or any chemotherapy. No prior bevacizumab, mTOR inhibitor, sunitinib, sorafenib or other VEGF TKI) for advanced or metastatic prostate cancer.
Must have metastatic diagnosis, meaning disease beyond the prostate gland.
A progressing PSA of ≥ 3, the PSA will be measured in ≥ 14 days.
KPS of ≥ 70
Age ≥ 18 years old
Adequate organ system functions:
Absolute neutrophil count (ANC) ≥ 1.5 X 109/L
Hemoglobin ≥ 9 g/dL
Platelets ≥ 100 X 109/L
International normalized ratio (INR) ≤ 1.2 X upper limit of normal (ULN)
Partial thromboplastin time (PTT) ≤ 1.2 X ULN
Total bilirubin ≤ 1.5 X ULN
AST and ALT ≤ 2.5 X ULN
Calculated creatinine clearance ≥ 30 mL/min
Urine Protein to Creatinine Ratio (UPC)2 < 1
Total serum calcium concentration < 12.0mg/dL
Left ventricular ejection fraction (LVEF) ≥ 55% as assessed by echocardiography or multigated acquisition (MUGA) scan. The same modality used at baseline must be applied for subsequent evaluations.
Exclusion criteria
Subjects meeting any of the following criteria must not be enrolled in the study:
History of another malignancy.
Note: Subjects who have had another malignancy and have been disease-free for 3 years, or subjects with a history of completely resected non-melanomatous skin carcinoma or successfully treated in situ carcinoma are eligible.
History or clinical evidence of central nervous system (CNS) metastases.
Note: Subjects who have previously-treated CNS metastases (surgery ± radiotherapy, radiosurgery, or gamma knife) and meet all 3 of the following criteria are eligible:
Clinically significant gastrointestinal abnormalities including, but not limited to:
Presence of uncontrolled infection.
Prolongation of corrected QT interval (QTc) > 480 milliseconds (msecs).
History of any one or more of the following cardiovascular conditions within the past 12 months:
History of cerebrovascular accident (CVA) including transient ischemic attack (TIA).
History of pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6 months. Note: Subjects with recent DVT who have been treated with therapeutic anticoagulating agents for at least 6 weeks are eligible.
Poorly controlled hypertension [defined as systolic blood pressure (SBP) of ≥150mmHg or diastolic blood pressure (DBP) of ≥ 90 mmHg].
Note: Initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry. Blood pressure must be re-assessed on two occasions that are separated by a minimum of 24 hours. The mean SBP/DBP values from each blood pressure assessment must be < 150/90mmHg in order for a subject to be eligible for the study. See Section 6.3.2 for instruction on blood pressure measurement and obtaining mean blood pressure values.
Prior major surgery or trauma within 28 days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer.
Evidence of active bleeding or bleeding diathesis
Hemoptysis within 6 weeks of first dose of study drug.
Any serious and/or unstable pre-existing medical, psychiatric, or other conditions that could interfere with subject's safety, obtaining informed consent or compliance to the study.
Prohibited medications within 28 days unless the half-life of the medication is longer than 28 days, will not be permitted.
Use of an investigational agent, including an investigational anti-cancer agent, within 28 days or 5 half-lives, whichever is longer, prior to the first dose of study drug.
Prior use of an investigational or licensed drug that targets VEGF or VEGF receptors (e.g., bevacizumab, sunitinib, sorafenib, etc), or are mTOR inhibitors (eg. temsirolimus, everolimus, etc).
Is now undergoing and/or has undergone in the last 4 weeks immediately prior to first dose of study drug, (surgery, tumor embolization, chemotherapy, radiation therapy, immunotherapy, or biological therapy)
Any ongoing toxicity from prior anti-cancer therapy that is > Grade 1 and/or that is progressing in severity.
Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib.
Primary purpose
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11 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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