PCA Administration in Prosthetic Joint Infection

Dr. Dean Reeves Clinic

Status: Not yet enrolling

Conditions: Prosthetic Joint Infection

Treatments: Dietary Supplement: Oral PCA

Study type: Interventional

Funder types: Other

Identifiers

NCT06591741

PCAinPJI-01

Details and patient eligibility

About

Determine if dietary protocatechuic acid (PCA) will affect health biomarkers in patient undergoing revision surgery for a knee prosthetic joint infection

Full description

Patients who are scheduled to undergo revision surgery for a knee prosthetic joint infection are given PCA prior to surgery for a time period determined by a previous pilot study. PCA is then post-operatively until anticoagulation is stopped, and then will be resumed for four years post revision surgery. Measurement of changes in glucose control, immunity, will be measured over the first 3 months post-revision, and the post-revision reinfection rate over the full 4 years will be compared to a cohort rate

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 3 weeks or more after total knee arthroplasty
• One or more symptoms of infection, including redness, swelling, pain, increasing range of motion loss, fever, nausea, and loss of appetite.
• WBC count of aspirate >50,000 cells per μL

Exclusion criteria

• Not willing to undergo blood draw at 3 months.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

PCA administraton

Other group

Treatment:

Dietary Supplement: Oral PCA