PCT and Clinical Algorithm for Determination of Duration of Antibiotics

Fraser Health

Status and phase: Completed; Phase 3

Conditions: Infection

Treatments: Other: PCT and clinical algorithm for stopping abx

Study type: Interventional

Funder types: Other

Identifiers

NCT01572831

FHREB 2011-089

Details and patient eligibility

About

Patients in the ICU whose infection is resolving will be randomized to standard duration of antibiotics compared to duration determined by a combination of a procalcitonin value and a simple evaluation of clinical status.

Enrollment: 1 patient

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (19 years and older) treated with ABx for reasons other than prophylaxis within the last 24 hours and who are admitted to a critical care environment.

Exclusion criteria

• Declined consent

• Any infection that according to evidence-based guidelines which would usually receive more than 2 weeks of antibiotic therapy including, but not limited to;

  • Infective endocarditis
  • Osteomyelitis
  • Undrained abscess

• Not expected to survive 48 hours

• Immunosuppression (HIV positive, any immunosuppressive medications, any steroid dose, neutrophil count less than 1.0)

• Previously enrolled in this study

• Presently enrolled in a separate study which is felt by study investigators to have biological or clinical process in conflict with this study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Quadruple Blind

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1 participants in 2 patient groups

standard care

No Intervention group

Description:

Abx will be determined by the managing physician

experimental arm

Experimental group

Description:

Abx determined by normalization of PCT and basic clinical parameters

Treatment:

Other: PCT and clinical algorithm for stopping abx