PD-1/PD-L1 Pathway Study on Septic Patients

Naval Military Medical University

Status: Completed

Conditions: Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT01161745

ANETHDEPT-001

Details and patient eligibility

About

The investigators want to identify that whether PD-1/PD-L1 pathway will change in human sepsis, and whether PD-1/PD-L1 pathway play an important role in sepsis induced immunosuppression.

Full description

First, we will detect PD-L1 expression on PBMC of septic patients and healthy controls.

Second, blockade of PD-1/PD-L1 pathway in vitro and stimulate with some biomolecules and then analyze the PBMC function and apoptosis by flow cytometry.

Then, compare with healthy controls and find the differences.

Enrollment: 39 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients who develop sepsis

Exclusion criteria

• patients with cirrhosis or renal dysfunction
• patients with dyscrasia
• patients with autoimmunity diseases
• patients with severe cardiac and pulmonary diseases
• patients with hematological diseases
• patients with diabetes mellitus
• patients with malignant tumors