PDIUC Protocol for Placental Accreta

Assiut University

Status: Unknown

Conditions: Placenta Accreta

Treatments: Procedure: PDI-UC protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT03273569

PDIUC001

Details and patient eligibility

About

The aim of this study is to evaluate a novel protocol to conserve the uterus during Cesarean delivery indicated for placenta accreta.

Full description

Placenta accreta is a morbid obstetric condition that describes variable non-physiologic invasion of the placenta into the the uterine wall. The incidence of placenta accreta, as a serious cause of postpartum hemorrhage, has substantially increased secondary to increase the rate of Cesarean delivery. Placenta accreta is primarily managed by peripartum hysterectomy prior to delivery of the placenta to avoid uncontrolled bleeding. However, in addition to the surgical risks, hysterectomy is psychologically morbid to many women particularly younger women and women with low parity. Therefore, several conservative options were studied to provide an alternative for hysterectomy in these women. Our study is designated to evaluate a proposed protocol of multi-step interventions to reduce the anticipated amount of bleeding prior to delivery of the placenta.

Enrollment: 30 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women with diagnosis of placenta accreta (US or MRI based diagnosis)
• Women who decline hysterectomy
• Pregnancy at 28 weeks of gestation or beyond
• Women who accept to participate in the study

Exclusion criteria

• Emergency Cesarean delivery (women with active bleeding)
• Women with cardiac diseases
• Women with coagulopathy

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Women with placenta accreta

Experimental group

Description:

PDI-UC protocol

Treatment:

Procedure: PDI-UC protocol