Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy

University of Pittsburgh

Status: Completed

Conditions: Duchenne Muscular Dystrophy

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02034305

PRO11100704

Details and patient eligibility

About

This study is to determine whether physiologic measures (peak cough flow, measures of respiratory muscle strength including MIP, MEP ,SNIP, and spirometry) can predict spontaneous cough clearance (as measured by a nuclear medicine study) in children with neuromuscular disease. It will also determine whether airway clearance is augmented by high frequency chest wall oscillation.

Enrollment: 7 patients

Sex: Male

Ages: 6 to 21 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 6-21; able to cooperate with study procedures
• Duchenne Muscular Dystrophy OR Becker Muscular Dystrophy

Exclusion criteria

• Need for mechanical ventilation during the day
• Recent (within 2 weeks) lower respiratory tract infection