Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Young Adults

Auburn University

Status: Completed

Conditions: Sarcopenia

Treatments: Dietary Supplement: Peanut protein powder; Behavioral: Full body resistance training

Study type: Interventional

Funder types: Other

Identifiers

NCT04707963

19-249B

Details and patient eligibility

About

This study will evaluate the adaptations in skeletal muscle that occur in response to 10 weeks of weight training with or without peanut protein supplementation in untrained men and women ages 18-30

Full description

This is a two-phase study using both novel and conventional methods to assess how PP supplementation affects muscle tissue in young adults who engage in resistance training. These two phases will be conducted as part of a 10-week randomized controlled trial in which men and women aged 18-30 years (n=40), will be stratified by gender and randomized to a resistance training intervention (whole body, two days per week) with PP powder (72g daily; n=10 males, n=10 females) provided during the intervention (immediate group, IG) or after the intervention (wait-list control, WLC, n=10 males, n=10 females). The aims of this study are to determine the acute (deuterium oxide tracer) and chronic (peripheral quantitative computed tomography) effects of PP during resistance training on skeletal muscle myofibrillar protein synthesis rates, changes in skeletal muscle size and quality, changes in whole and appendicular body composition (dual energy x-ray absorptiometry), changes in inflammatory markers and the fecal microbiome.

Enrollment: 56 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• body mass index (body mass/height squared) less than 35 kg/m2
• resting blood pressure averaging less than 140/90 mmHg (with or without medication)

Exclusion criteria

• known peanut allergy
• actively participating in resistance training for more than 2 days/week
• any known overt cardiovascular or metabolic disease
• metal implants that will interfere with x-ray procedures
• medically necessary radiation exposure in the last six months (except dental x-ray)
• any medical condition that would contradict participating in an exercise program, giving blood or donating a skeletal muscle biopsy (i.e. blood clotting disorder or taking blood thinners)
• pregnant or trying to become pregnant

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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56 participants in 2 patient groups

Immediate Intervention Group

Experimental group

Description:

Participants will complete 10 weeks of twice-weekly whole body resistance training. Peanut protein powder (72g/day) will be provided for daily consumption during the study period

Treatment:

Behavioral: Full body resistance training

Dietary Supplement: Peanut protein powder

Wait-list Control Group

Active Comparator group

Description:

Participants will complete 10 weeks of twice-weekly whole body resistance training. Peanut protein powder will be provided after the study period

Treatment:

Behavioral: Full body resistance training