Peanuts Second Meal Glycemic Response

Federal University of Vicosa

Status: Completed

Conditions: Type 2 Diabetes Mellitus

Treatments: Dietary Supplement: Whole peanuts without skins, Peanut butter, or no peanuts (control)

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT01413126

NUTBRA

Details and patient eligibility

About

Nut consumption is associated with reduced risk of Type 2 diabetes. The aim of this study was to assess the effects of peanut (whole or peanut butter) to breakfast meals on glycemic, insulinemic and selected gut hormone responses, appetite, and food intake over two consecutive meals in obese women with high Type 2 diabetes risk. Fifteen women participated in a randomized crossover trial where 42.5g of whole peanuts (P), peanut butter (PB), or no peanuts (control-C) were added to a 75g available carbohydrate-matched breakfast meal. Postprandial concentrations of blood glucose, insulin, non-esterified free fatty acids (NEFA), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), cholecystokinin (CCK), appetitive sensations and food intake were assessed after breakfast treatments and a standard lunch (75g available carbohydrate).

Enrollment: 15 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Body mass index between 30 - 35 kg/M2
• Not taking medications known to affect glycemia, fat metabolism, or appetite
• Regular breakfast consumer (≥100 kilocalories ingested within 2 hours of waking on ≥4d/wk)
• No body weight fluctuation (<5kg in the past 3 months)
• Willingness to eat all test foods
• No self-reported allergy to the foods provided in the study
• No self-reported sleep disorders
• At least one of the following conditions: waist circumference ≥ 88 cm; reported family history of Type 2 diabetes in first degree relatives; capillary glycemia between 5.5 - 7.0 mmol/L; and/or a 2-hour blood glucose of 7.8 - 11.1 mmol/L (impaired glucose tolerance)

Exclusion criteria

• Type 2 diabetes mellitus
• Dyslipidemia
• High blood pressure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 3 patient groups

Peanut butter

Experimental group

Description:

42.5 g of Peanuts butter were added to a 75g available carbohydrate-matched breakfast meal

Treatment:

Dietary Supplement: Whole peanuts without skins, Peanut butter, or no peanuts (control)

Whole peanut

Experimental group

Description:

42.5 g of whole peanuts were added to a 75g available carbohydrate-matched breakfast meal

Treatment:

Dietary Supplement: Whole peanuts without skins, Peanut butter, or no peanuts (control)

No peanuts (control)

No Intervention group

Treatment:

Dietary Supplement: Whole peanuts without skins, Peanut butter, or no peanuts (control)