Pearls and Pitfalls in Usage of Plasma-Rich Platelet Graft Versus Dartos Flap in Distal Penile Hypospadias Repair

Assiut University

Status: Not yet enrolling

Conditions: Penile Hypospadias

Treatments: Procedure: Dartos Flap; Procedure: Plasma-Rich Platelet Graft

Study type: Interventional

Funder types: Other

Identifiers

NCT06808139

PRPgraft/DartosflapHypospadias

Details and patient eligibility

About

Hypospadias is the most common congenital anomaly of penis. It is the second most common genital birth defect in boys after cryptorchidism The reinforcement of hypospadias repair with an intermediate layer is believed to reduce the incidence of postoperative complications such as uretherocautanous fistula.

Hypospadias is classified by the location of the abnormal urethral meatus into distal penile (glandular ,subcoronal and distal penile), mid penile and proximal penile hypospadias Indeed, uretherocautanous fistula is most common complication after urethroplasty, with introduction of a protective layer between the neourethra and the covering skin strongly reduces fistulas occurrence and the overall complication the aim of the study To evaluate and to compare the use of PRP covering layer and dartos fascia flap layer in regard to complication rates in hypospadias repair

Full description

Hypospadias is the most common congenital anomaly of penis. It is the second most common genital birth defect in boys after cryptorchidism The reinforcement of hypospadias repair with an intermediate layer is believed to reduce the incidence of postoperative complications such as uretherocautanous fistula.

Hypospadias is classified by the location of the abnormal urethral meatus into distal penile (glandular ,subcoronal and distal penile), mid penile and proximal penile hypospadias Indeed, uretherocautanous fistula is most common complication after urethroplasty, with introduction of a protective layer between the neourethra and the covering skin strongly reduces fistulas occurrence and the overall complication the aim of the study To evaluate and to compare the use of PRP covering layer and dartos fascia flap layer in regard to complication rates in hypospadias repair

Enrollment: 70 estimated patients

Sex: Male

Ages: 6+ months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >6 months
• Distal penile hypospadias
• Denovo hypospadias

Exclusion criteria

• Recurrent hypospadias -Mid and proximal penile hypospadias

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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70 participants in 2 patient groups

Group A

Active Comparator group

Description:

Plasma-Rich Platelet Graft

Treatment:

Procedure: Plasma-Rich Platelet Graft

Group B

Active Comparator group

Description:

Dartos Flap

Treatment:

Procedure: Dartos Flap