Pediatric Antibiotic Associated Diarrhea (TURPENADA)

Hacettepe University

Status: Unknown

Conditions: Diarrhea

Study type: Observational

Funder types: Other

Identifiers

NCT03265730

Hacettepe01

Details and patient eligibility

About

Diarrhea is one of the side effects of antibiotics. Antibiotic associated diarrhea can be encountered between two hours to two months after starting of antibiotics. The purpose of the study is to determine incidence,risk factors and severity of pediatric antibiotic associated diarrhea in Turkey.

Full description

Antibiotic associated diarrhea is a common adverse effect, occurring about 5-30% of patients either early during treatment or up to two months after the cessation of the treatment. The frequency differs according to the definition of diarrhea, the inciting antimicrobial agent and the host factors such geriatric age, immunosuppression, prolonged hospitalization. Almost all agents, especially the the ones acting on anaerobes may cause diarrhea. Clinical presentations range from mild diarrhea to fulminant pseudomembranous enterocolitis. In Turkey still data about antibiotic associated diarrhea is not enough. Incidence and the factors that effect severity are not known.

Enrollment: 2,000 estimated patients

Sex: All

Ages: 1 month to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The parents and the child who give consent
• The children who are treated for the acute infections in the outpatient clinics and whole treatment is completed in the outpatient clinics.
• Children who are born mature, for the children who are younger than 1 year of age.

Exclusion criteria

• The parents and child who do not give consent
• Children who have primary and secondary immunosuppressive states.
• Children who had abdominal/gastrointestinal tract surgery in the past.
• Children who had used probiotics/prebiotics in the last one month period.
• Children who had used antibiotics in the last one month period.
• Children who has accompanying gastrointestinal symptoms.
• Children who are using anti-acid treatment at the time of involvement.