Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)

Children's Hospital Los Angeles

Status: Enrolling

Conditions: Pediatric Acute Respiratory Distress Syndrome

Treatments: Device: Electrical Impedance Tomography positive end-expiratory pressure titration

Study type: Interventional

Funder types: Other

Identifiers

NCT06684119

CHLA-24-00295

Details and patient eligibility

About

The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced. The primary and secondary aims of the study are as follows:

Identify the difference between the optimal PEEP recommended by EIT metrics and the current guideline recommended approach to identifying optimal PEEP in PARDS. There will be a statistically significant difference in the recommended optimal PEEP identified using the EIT PEEP titration tool and that of the PEEP/FiO2 grid recommendations.

Determine the difference in physiologic metrics between EIT optimal PEEP and the PEEP/FiO2 recommended PEEP.

Participants will undergoing EIT monitoring while being subjected to PEEP titration protocol.

Enrollment: 60 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any person who is less than 18 years of age
• is on invasive mechanical ventilation
• is not spontaneously breathing
• meets PARDS criteria

Exclusion criteria

• Contraindication to the use of EIT
• Hemodynamic instability
• Contraindications to hypercapnia
• patients with uncuffed endotracheal or tracheostomy tubes
• diagnosis of pneumothorax or bronchopleural fistula
• non-conventional ventilation
• any patient on extra-corporeal membrane oxygenation (ECMO) support
• less than 1 week post-operatively from cardiac surgery
• the following cardiac diagnoses: Glenn or Fontan physiology, significant right to left shunt
• Corrected Gestational Age < 37 weeks
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

Electrical Impedance Tomography positive end-expiratory pressure

Experimental group

Description:

Patients will be monitored using Electrical Impedance Tomography and the positive end-expiratory pressure titration tool as their positive end-expiratory pressure is adjusted according to a step wise positive end-expiratory pressure titration protocol.

Treatment:

Device: Electrical Impedance Tomography positive end-expiratory pressure titration