PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury (PRE-VIKI)

Università degli Studi di Ferrara

Status: Completed

Conditions: Respiration, Artificial; Acute Kidney Injury; Respiratory Distress Syndrome, Adult

Treatments: Procedure: PEEP changes

Study type: Observational

Funder types: Other

Identifiers

NCT03969914

RRIPEEP

Details and patient eligibility

About

The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. Many parameters have been described as influential on the values of renal RI. Mechanical ventilation is associated with significant increases in the risk of acute kidney injury (AKI). Ventilator-induced kidney injury (VIKI) is believed to occur due to changes in hemodynamics that impair renal perfusion. The investigators hypothesized that patients who need mechanical ventilation should have a different response in RRI when different levels of Positive end expiratory pressure (PEEP) are applied. Investigators wish to describe changing in RRI due to changes in PEEP and to verify whether these changes could partially explain the occurrence of VIKI

Enrollment: 105 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients admitted to ICU with expected mechanical ventilation >48h

Exclusion criteria

• Ultrasound RRI evaluation non available
• Patients with arrhythmia
• Pregnancy

Trial design

105 participants in 1 patient group

Critically ill ventilated patients

Description:

Patients admitted to ICU with expected mechanical ventilation \>48h

Treatment:

Procedure: PEEP changes