Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

Thomas Jefferson University

Status: Enrolling

Conditions: Stage IV Prostate Cancer AJCC v8; Stage IIIC Prostate Cancer AJCC v8; Stage IIIB Prostate Cancer AJCC v8; Metastatic Prostate Carcinoma

Treatments: Other: Educational Intervention; Procedure: Discussion; Behavioral: Training and Education

Study type: Observational

Funder types: Other

Identifiers

NCT05627219

22C.423

JT 22046 (Other Identifier)

Details and patient eligibility

About

This trial evaluates whether a network of peer genetic coaches is useful for addressing disparities in genetic testing and screening among African American men with prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic). While genetic testing has become central to prostate cancer care, African American men are less likely seek testing due to lack of awareness, cultural beliefs, financial limitations, fear of discrimination, and mistrust in the healthcare system. A network of peer genetic coaches may help address barriers, beliefs, and needs of African American men in the community and provide navigation to increase engagement in genetic testing.

Full description

PRIMARY OBJECTIVES:

I. Identify and train 6 African American (AA) men as peer genetic coaches (PGCs) for the Extending Prostate Genetic Awareness, Navigation, and Delivery (EXPAND) Network. (Train peer genetic coaches) II. Conduct a feasibility study of peer genetic coaching. (Provide individual coaching)

SECONDARY OBJECTIVE:

I. Patient-related outcomes will include change in decisional conflict for genetic counseling, acceptability/attitude toward genetic counseling and testing, and change of genetics knowledge.

OUTLINE:

AIM 1: Peer genetic coaches undergo training and education on study.

AIM 2: Patients receive an educational booklet and attend a discussion with a peer genetic coach on study.

Enrollment: 30 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• AIM 1: Are 18 years old or older
• AIM 1: Are able to read and speak English comfortably
• AIM 1: Men who have experience with both prostate cancer (PCA) and genetic counseling and testing will be a priority for training, as well as men who have considerable peer education or navigation experience
• AIM 2: Are 18 years old or older
• AIM 2: Are African American
• AIM 2: Are able to read and speak English comfortably
• AIM 2: Men who meet any one of the following criteria: (1) metastatic prostate cancer; (2) prostate cancer with high-risk features (T3 or higher, Gleason 8 or higher, node positive disease); (3) with or without a diagnosis of prostate cancer with strong family history (2 or more first-degree or second-degree relatives) with prostate cancer (particularly metastatic prostate cancer or died from prostate cancer), breast cancer, ovarian cancer, pancreatic cancer, colorectal cancer, uterine cancer, renal cancer, urothelial cancer, or upper bowel cancer

Exclusion criteria

• Patients that do not meet the inclusion criteria
• Children under the age of 18
• Anyone who has trouble understanding the consent or with significant anxiety detected during the consent process

Trial design

30 participants in 1 patient group

Supportive care (training, education, discussion)

Description:

AIM 1: Peer genetic coaches undergo training and education on study. AIM 2: Patients receive an educational booklet and attend a discussion with a peer genetic coach on study.

Treatment:

Behavioral: Training and Education

Procedure: Discussion

Other: Educational Intervention