Peking University Birth Cohort in Tongzhou (PKUBC-T)

Peking University

Status: Active, not recruiting

Conditions: Anemia; Gestational Diabetes; Child Development; Health Problems in Pregnancy; Gestational Hypertension; Mother-Infant Interaction; Obesity; Pregnancy Outcomes; Preterm Birth

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT03814395

NNSF81703240

81703240 (Other Grant/Funding Number)

Details and patient eligibility

About

The PKUBC-T is a prospective cohort study carried out in Tongzhou district of Beijing, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to 6 years old. Biological samples including blood and tissue samples are also collected from mothers and their children.

Full description

Maternal and child health is of great concern globally. Early life phase of a fetus and infant is a critical period for the development of health and disease in the whole life. Exposure of negative environmental, nutritional and lifestyle factors in pregnant women during this period can have adverse effects on fetal and infant. In addition, for mothers, complications during pregnancy could also have a negative effect on long-term health of mothers, such as diabetes, hypertension. Thus, the Peking University Birth Cohort in Tongzhou is primarily aimed to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to 6 years old. Biological samples including blood and tissue samples are also collected from mothers and their children.

Enrollment: 5,426 estimated patients

Sex: Female

Ages: 18 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Pregnant women, <14 gestational weeks
2. Resided in Tongzhou in the past half years and have no plan to move out after delivery
3. Pregnant women who plan to have antenatal care and delivery in Tongzhou maternal&Child Hospital.
4. Pregnant women who is willing to participate in this study with informed consent

Exclusion criteria

Pregnant women have chronic disease before pregnancy, including diabetes，hypertension, liver disease and kidney disease.

Trial design

5,426 participants in 2 patient groups

Exposure group

Description:

Group with environmental, nutritional or lifestyle exposures

Treatment:

Other: No intervention

Non-exposed group

Description:

Group without any environmental, nutritional and lifestyle exposures