Pelvic Microbiomes of Benign and Malignant Ovarian Diseases (MTBOD-1)

Lei Li

Status: Unknown

Conditions: Ovarian Neoplasms; Ribosome Alteration; Microbiota

Treatments: Diagnostic Test: microbiomes

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT03388996

MTBOD-1

Details and patient eligibility

About

This case-control study aims to compare the pelvic microbiomes of benign ovarian diseases and ovarian malignancies by 16s RNA techniques and culture. Discharges/flushing fluid from vagina, faces and fimbria end of fallopian tube are collected from age and menopausal status matched patient before and during procedures of laparoscopies. The discharges/flushing fluid would be sent for 16s RNA analysis and microculture respectively, and the results would get self-contrasted comparison and case-control comparison.

Enrollment: 40 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Laparoscopy procedures
• Specific pathological diagnosis

Exclusion criteria

• Previous history of pelvic surgeries
• Evidences of pelvic inflammation diseases

Trial design

40 participants in 2 patient groups

Benign ovarian disease

Description:

The group consists of patients of benign ovarian diseases and health conditions (eg infertility), who would accept the tests of pelvic microbiomes.

Treatment:

Diagnostic Test: microbiomes

Malignant ovarian disease

Description:

The group consists of patients of high grade serous carcinoma, who would accept the tests of pelvic microbiomes.

Treatment:

Diagnostic Test: microbiomes