Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs

Indiana University School of Medicine

Status and phase

Completed

Phase 4

Conditions

Cataract

Treatments

Drug: Levofloxacin 0.5%

Drug: Ciprofloxacin 0.3%

Drug: Levofloxacin 250mg

Drug: Ofloxacin 400mg

Drug: Ofloxacin 0.3%

Drug: Ciprofloxacin 400mg

Study type

Interventional

Funder types

Other

Identifiers

NCT00392275

0208-29

Details and patient eligibility

About

Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.

Full description

The purpose of this study is to assay human aqueous for concentrations of ofloxacin, ciprofloxacin and levofloxacin after topical or combined topical and oral administration in eyes with filtering blebs.

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

All patients with functioning filtering blebs will be evaluated prospectively for inclusion

Exclusion criteria

Any subject who is already scheduled to have cataract surgery performed will qualify for participation with the exception of the following exclusion criteria:
- Ongoing ocular inflammatory disease
- Bleb leakage - determined by Seidel test
- Suspected infection
- Known contraindications to use of any of these study medications.
- Pregnancy