Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams

Chulalongkorn University

Status: Completed

Conditions: Penicillin Allergy

Treatments: Procedure: Immediate skin test

Study type: Interventional

Funder types: Other

Identifiers

NCT00789217

Chula-ARC 001/08

Details and patient eligibility

About

This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicillin testing kit.

Full description

The results of skin test with immediate reading will be compared between alkali-treated penicillin G and DAP reagents from Diater

Enrollment: 63 patients

Sex: All

Ages: 15 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients with history of hypersensitivity reactions to betalactams; penicillin, aminopenicillins, and cephalosporins
2. 15-65 years of age

Exclusion criteria

1. On antihistamine/ cannot discontinue antihistamine before the test
2. Having asthma exacerbation
3. Being pregnant
4. Suffering from severe systemic disease/ in bad health

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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63 participants in 3 patient groups

In-house penicillin testing preparation

Active Comparator group

Description:

In-house penicillin testing prepared from alkali-treated penicillin G

Treatment:

Procedure: Immediate skin test

Commercial penicillin test kit

Active Comparator group

Description:

Commercial penicillin test kit order from Diater company

Treatment:

Procedure: Immediate skin test

Penicillin G Sodium

Active Comparator group

Description:

Penicillin G Sodium from routine clinical use

Treatment:

Procedure: Immediate skin test