People Living With HIV/AIDS, Nitrate, Endotelial Function, Arterial Stiffness and Skeletal Muscle Oxygenation

Universidade Federal do Rio de Janeiro

Status: Completed

Conditions: HIV/AIDS

Treatments: Dietary Supplement: Beetroot Juice; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03485248

68923417.0.0000.5699

Details and patient eligibility

About

Administration of antiretroviral therapy has brought benefits for infective human immunodeficiency virus-1 (HIV-1)-patients, reducing the number of AIDS-related morbidity and mortality. However, it is responsible for intensifying complications triggered by the chronic inflammatory state associated with virus infection, such as cardiovascular diseases. The current study evaluated effects of single dose (140mL) of Beetroot Juice (BJ) on macro and microvascular endothelial function in HIV-1-patients undergoing antiretroviral terapy, once BJ was shown to be effective in improving these physiological parameters in uninfected individuals.

Enrollment: 12 patients

Sex: All

Ages: 18 to 59 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• HIV infection for a period of 1 year or greater
• Regular use of high-potency antiretroviral therapy for at least one year

Exclusion criteria

• Individuals who are physically active
• Individuals who are allergic to some component of beet
• Individuals who use nutritional and / or pharmacological ergogenics
• Individuals receiving antibiotics or who have osteomioarticular problems

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups, including a placebo group

Beetroot juice

Active Comparator group

Description:

Beetroot Juice cotaining on average 9mmol of nitrate per dose

Treatment:

Dietary Supplement: Beetroot Juice

Placebo beet juice (Nitrate depleted)

Placebo Comparator group

Description:

Beetroot juice nitrate depleted

Treatment:

Dietary Supplement: Placebo