PerAF: AF Termination vs Prespecified Ablation

Shanghai Jiao Tong University

Status

Completed

Conditions

Persistent Atrial Fibrillation

Treatments

Procedure: Atrial Fibrillation Termination

Procedure: Prespecified Ablation

Study type

Interventional

Funder types

Other

Identifiers

NCT06837441

TPAF

Details and patient eligibility

About

The design of this study is an intervention, randomized, controlled study and contains two randomized groups：（1）AF-termination group；（2）Prespecified-ablation group.

Enrollment

195 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

aged between 18 and 80 years old;
Patients undergoing a first-time ablation procedure for PersAF, and in spontaneous AF at the beginning of the procedure;
Diagnosed as persistent AF according to the latest clinical guidelines，with atrial fibrillation lasting for at least one month;
Ineffective or intolerable to ≥1 anti-arrhythmia drug treatment;
Patients must be able and willing to provide written informed consent to participate in this study;
Patients must be willing and able to comply with all study follow- up requirements.

Exclusion criteria

.Uncontrolled congestive heart failure, EF <35%;
. History of severe valve disease and/or prosthetic valve replacement;
. Myocardial infarction or stroke within 6 months;
. Severe congenital heart disease;
. Left atrial diameter ≥60mm;
. Contrast agent allergy;
. The use of anticoagulant drugs is contraindicated;
. Severe lung disease;
. Left atrial thrombus confirmed by preoperative esophageal ultrasound;
.Contraindications for cardiac catheterization;
.Prior left atrial ablation (surgical or catheter);
.Have performed any cardiac surgery within 2 months;
.Poor general health;
.Life expectancy < 12 months, including factors such as physical inability to tolerate ablation or unstable disease conditions.-