Perception of Baby's Painful Cry in fMRI

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Neuronal Activity; Magnetic Resonance Imaging

Treatments: Other: functional Magnetic Resonance Imaging (fMRI)

Study type: Interventional

Funder types: Other

Identifiers

NCT03190486

1708071

ID-RCB (Other Identifier)

Details and patient eligibility

About

Crying is the primary signaling strategy available to the human newborn for eliciting parental care. Yet, the investigators only have superficial understanding of the information carried by cries, and how this information is perceived by parents. Using modern tools of sound processing and functional Magnetic Resonance Imaging (fMRI) experiment, this study aims to investigate cry-induced brain activation in adult depending on the cry's acoustic properties expressing various degrees of stress and distress levels. For that, Adults will be tested inside a fMRI magnet to determine their brain activations elicited by different babies cries according to whether the cry was evoked in a pain situation or not. The cerebral activity will be investigated in relation to acoustic features of cries (e.g. with pitch and/or roughness variations). To test if the gender or parentally of adult listeners influence their perceptions and brain responses, the task will be applied to 2 different groups (men and women not-parents). The hypothesis is that the brain of adult listeners will be able to discriminate adequately the intensity of the pain mediated by the cries. This process should involve brain areas such as the insular and the orbito frontal cortex that are known to participate in the integration of pain intensity and pain controls. The experiment should also determine which one of the acoustic features is able to transmit pain and to recruit brain areas involved in pain processes.

Enrollment: 80 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Man or woman aged between 18 and 50
• Contact-less with children
• right-handed
• Giving their written informed consent
• Subject who agreed to communicate MRI results to their attending physician
• French Social Security affiliation

Exclusion criteria

• any contraindications to pass an fMRI test
• Pregnant woman

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 4 patient groups

Men contact-less with children

Experimental group

Description:

functional Magnetic Resonance Imaging (fMRI).

Treatment:

Other: functional Magnetic Resonance Imaging (fMRI)

Women contact-less with children

Experimental group

Description:

functional Magnetic Resonance Imaging (fMRI).

Treatment:

Other: functional Magnetic Resonance Imaging (fMRI)

Father contact-less with children

Experimental group

Description:

functional Magnetic Resonance Imaging (fMRI).

Treatment:

Other: functional Magnetic Resonance Imaging (fMRI)

Mother contact-less with children

Experimental group

Description:

functional Magnetic Resonance Imaging (fMRI).

Treatment:

Other: functional Magnetic Resonance Imaging (fMRI)