Percutaneous Tumor Ablation Vs Partial Nephrectomy for Small Renal Mass: the Impact of Histologic Variant and Tumor Size (CRYO-BO-2021)

Scientific Institute for Research Hospitalization and Healthcare (IRCCS)

Status

Completed

Conditions

Renal Cell Cancer

Study type

Observational

Funder types

Other

Identifiers

NCT06829888

CRYO-BO-2021

Details and patient eligibility

About

The aim, of this study is to investigate recurrence rates in patients with T1 renal cell carcinoma (RCC) undergone partial nephrectomy (PN), radiofrequency ablation (RFA) or cryoablation (Cryo).

Full description

The aim of our study was to compare oncologic outcomes in terms of recurrence and competing causes of mortality in patients undergone either PN, radiofrequency ablation (RFA) or cryoablation (Cryo) focusing on tumor volume and histologic variant. Retrospectively were evaluated data from 665 (81.4%), 68 (8.3%) and 83 (10.3%) patients who underwent PN, RFA and Cryo, respectively. Kaplan-Meier curves depict recurrence-free survival (RFS) rates in the overall population and after stratifying according to tumor's histology (namely, clear cell RCC and non-clear RCC) and size (namely <2 cm and 2-4 cm). Multivariable Cox regression model was used to identify predictors of recurrence. Cumulative-incidence plots evaluated disease recurrence and other causes of mortality (OCM).

Enrollment

955 patients

Sex

All

Ages

18 to 82 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Radiologic diagnosis (CT chest-abdomen or MRI abdomen with contrast medium) of renal neoplasm
Renal neoplasm of clinical stage T1a (≤4 cm) N0M0
Age >18 years
Informed consent
Absence of other neoplasm

Exclusion criteria

Patients refuse partial nephrectomy and/or percutaneous renal CA and are candidates for active surveillance
Patients who are candidates for radical nephrectomy