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Performance-based Reinforcement to Enhance Cognitive Remediation Therapy

Yale University logo

Yale University

Status

Completed

Conditions

Mental Disorders
Substance-Related Disorders

Treatments

Behavioral: Cognitive Remediation Therapy plus Contingency Management
Behavioral: Cognitive Remediation Therapy - Standard

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT01633138
1205010253
P50DA009241 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to investigate whether monetary reinforcement for performance will enhance the effects of cognitive remediation therapy for substance users seeking treatment at an outpatient facility.

Full description

Forty individuals seeking treatment for an alcohol or cocaine use disorder at the Substance Abuse Treatment Unit (SATU) will be randomized to receive cognitive remediation therapy with or without additional compensation based on performance. Participants will use the computerized cognitive remediation program (PSSCogRehab 2012) three times per week for four weeks. The primary outcome measure will be an improved performance on the computerized tasks, with secondary outcomes of changes in cognitive functioning (e.g., attention, concentration, memory) as measured by neuropsychological tests between baseline and post-treatment.

Enrollment

40 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 18 to 60 years old
  • Primary Alcohol and/or Cocaine Abuse/Dependence Diagnosis
  • Abstinence from all drugs/alcohol for 30 days
  • Mild cognitive impairment
  • Sufficiently stable and plan to commit to 4 weeks of outpatient treatment
  • Fluent in English and 6th grade reading ability

Exclusion criteria

  • Severe cognitive impairment indicative of dementia
  • Untreated bipolar or psychotic disorder
  • Have current legal case pending such that incarceration during 4-week study is likely

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

40 participants in 2 patient groups

CRT-S
Active Comparator group
Description:
Cognitive Remediation Therapy - Standard
Treatment:
Behavioral: Cognitive Remediation Therapy - Standard
CRT-CM
Experimental group
Description:
Cognitive Remediation Therapy plus Contingency Management
Treatment:
Behavioral: Cognitive Remediation Therapy plus Contingency Management

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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