Performance of Novel Simplified Score for Chronic Hepatitis B Treatment Eligibility in Thailand

Mahidol University

Status: Unknown

Conditions: Chronic Hepatitis B

Treatments: Diagnostic Test: TREAT-B score

Study type: Observational

Funder types: Other

Identifiers

NCT05295914

Si 745/2021

Details and patient eligibility

About

International and national guideline for chronic hepatitis B (HBV) infection treatment recommend initiated antiviral in high HBV viral loads patients with significant liver inflammation and significant liver fibrosis. In Thailand, HBV viral loads and liver elastography are limited available in seconds to tertiary care hospital.

Recently, many of simplified scoring system (TREAT-B score, WHO (World Health Organization)-simplified score and REACH-B score) were developed for assessment of antiviral initiation.

This study aim to evaluate the performance of simplified score for chronic HBV treatment compare to Thailand and international standard guideline.

Full description

According to WHO Global health sector strategy on viral hepatitis 2016- 2021, WHO aim to global eliminate HBV infection within 2030. Main strategies for achievement are effective prevention and treatment.

International and national guideline for HBV infection treatment recommend initiated antiviral in high HBV viral loads patients with significant liver inflammation and significant liver fibrosis. Thus, HBV viral load and liver elastography are required for indication assessment. In low-to-middle income country such as Thailand, HBV viral loads and liver elastography are limited available in seconds to tertiary care hospital.

Recently, many of simplified scoring system (TREAT-B score, WHO-simplified score and REACH-B score) were developed for assessment of antiviral initiation.

This study aim to evaluate the performance of simplified score for chronic HBV treatment compare to Thailand and international standard guideline.

Enrollment: 600 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Treatment naive chronic hepatitis B infection patients who visited at liver clinic and internal medicine clinic Siriraj hospital during January 2015-December 2021
• Age > 18 years

Exclusion criteria

• Treatment experience chronic hepatitis B infection patients
• HIV co-infection
• HCV (hepatitis C) co-infection
• concomitant HCC (hepatocellular carcinoma)
• Pregnancy
• Incomplete data

Trial design

600 participants in 1 patient group

Patient with chronic hepatitis B infection

Description:

Patient with chronic hepatitis B infection visited at liver and internal medicine clinic, Siriraj hospital between January 2015-2020

Treatment:

Diagnostic Test: TREAT-B score