Performance of Spectral CT-scan in Patients With Metastatic Colorectal Cancer: a Prospective Multicentre Study

Centre Hospitalier Universitaire de Saint Etienne

Status

Enrolling

Conditions

Colo-rectal Cancer

Treatments

Other: CT Images

Study type

Observational

Funder types

Other

Identifiers

NCT06024837

IRBN1162022/CHUSTE

Details and patient eligibility

About

Spectral CT is a rapidly expanding imaging modality that allows a reduction in iodine dose and irradiation compared to conventional scanning. It uses the difference in attenuation of the material according to the two different energy levels of the incident x-ray beams. The dual-energy scanner has a wide range of clinical applications, particularly in abdominal imaging.

Full description

First of all, the virtual creation of mono-energy images between 40 and 140 keV has shown subjective and objective improvement of tumor detection of hypovascular lesions using low energies (40keV). It has been shown to be of interest in vascular and cardiac imaging, and to reduce artefacts in bone imaging. However, its performance in oncology analysis has been little studied. The selection of patients for peritoneal and hepatic carcinosis surgery is fundamental, as surgery allows a prolongation of survival, but are associated with a non-negligible morbi-mortality rate.

Spectral CT provides improved detection of peritoneal carcinosis and liver metastases of colorectal cancer compared to conventional CT acquisition.

Enrollment

100 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients followed for colorectal cancer with synchronous or metachronous liver metastases and/or peritoneal carcinosis
Patients with a curative surgical resection plan

Exclusion criteria

Patients with non-metastatic colorectal cancer
Patients treated with chemotherapy without surgical plans
Patients with colorectal cancer with extra-hepatic and extra-peritoneal metastases alone (e.g. lung, bone)