Perfusion and Hypoxia Evaluation in Tumors Using 18F-FDG PET/CT

Harbin Medical University

Status: Unknown

Conditions: Perfusion and Hypoxia

Treatments: Diagnostic Test: 18F-FDG PET/CT initial-time imaging; Diagnostic Test: 18F-FDG PET/CT balanced-time imaging

Study type: Observational

Funder types: Other

Identifiers

NCT03373994

14008 (Other Identifier)

Details and patient eligibility

About

Investigators want to use 18F-FDG PET/CT imaging to reflect tumor perfusion and hypoxia.

Full description

Perfusion and hypoxia were independent prognositic parameters for tumor patients. Developing a method that can evaluate tumor perfusion and hypoxia noninvasively and conveniently was in urgent need. 18F-FDG PET/CT imaging could reflect tumor hypoxia in 60min balanced imaging was proved and accepted. Moreover, FDG could diffuse out of the vasculature and through cell membranes passively and rapidly due to its lipophilicity, its regional uptake at initial times is expected to reflect tumor perfusion. So, investigators want to use 18F-FDG PET/CT imaging to evaluate tumor perfusion and hypoxia simutaniously，in order to guide the clinical diagnosis and treatment.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1.solid tumor proved by pathology(d>3.0cm);
• 2.age>18-year-old;
• 3. Karnofsky performance status >70;
• 4.sign the informed consent.

Exclusion criteria

• 1.There are obvious metal implants near the tumor;
• 2.Can not lie still for 15 minutes.
• 3.Pregnancy.

Trial design

40 participants in 2 patient groups

18F-FDG PET/CT initial-time imaging

Description:

PET/CT imaging was underwent 5min after 18F-FDG injection.

Treatment:

Diagnostic Test: 18F-FDG PET/CT initial-time imaging

18F-FDG PET/CT balanced-time imaging

Description:

PET/CT imaging was underwent 60min after 18F-FDG injection.

Treatment:

Diagnostic Test: 18F-FDG PET/CT balanced-time imaging