Perfusion Assessment of Wound Closure Techniques in Primary Total Knee Arthroplasty

Mayo Clinic

Status: Completed

Conditions: Total Knee Arthroplasty

Treatments: Procedure: Staple Closure; Procedure: Running Subcuticular Closure; Procedure: Vertical Mattress Closure

Study type: Interventional

Funder types: Other

Identifiers

NCT01924403

13-005083

Details and patient eligibility

About

This study will assess which of the three most common methods of wound closure in primary total knee arthroplasty (staples, interrupted vertical mattress, or running subcuticular suture) provide the best wound vascular perfusion. This can be achieve by using SPY intra-operative vascular angiography, which is commonly used in clinical practice to assess perfusion of wound closure at the clinic. By understanding the differences in perfusion afforded by different closure techniques, surgeons will then be able to select the technique that optimizes this parameter so as to avoid complications such as tissue necrosis, wound dehiscence, or infection.

Enrollment: 45 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ≥ 18 years old
• Primary diagnosis of osteoarthritis
• Surgical indication for index total knee arthroplasty

Exclusion criteria

• Previous surgery about the knee
• Systemic corticosteroid use
• Active infection of any kind or chronic infection with HIV, Hepatitis C, or Syphilis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

45 participants in 3 patient groups

Staple Closure

Experimental group

Description:

Staple closure will be one technique employed to close the wound in primary total knee arthroplasty.

Treatment:

Procedure: Staple Closure

Running Subcuticular Closure

Experimental group

Description:

Running subcuticular closure will be one technique employed to close the wound in primary total knee arthroplasty.

Treatment:

Procedure: Running Subcuticular Closure

Vertical Mattress Closure

Experimental group

Description:

Vertical mattress closure will be one technique employed to close the wound in primary total knee arthroplasty.

Treatment:

Procedure: Vertical Mattress Closure