Perfusion Imaging With Myocardial Contrast Echocardiography in HCM

Oregon Health & Science University (OHSU)

Status: Unknown

Conditions: Hypertrophic Cardiomyopathy

Treatments: Drug: Echo and myocardial contrast echocardiography perfusion imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT02560467

15158

Details and patient eligibility

About

The objective of this study is to determine whether myocardial contrast echocardiography in patients with cardiomyopathy (HCM) can detect resting hypo-perfusion due to fibrosis or stress induced perfusion defects due to associated abnormalities in intramyocardial arteries and the microcirculation. A secondary aim will be to determine whether abnormalities in perfusion are associated with either severity of symptoms (chest pain and dyspnea), presence of arrhythmias, and regional function of the septum.

Enrollment: 10 patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-80 years
• Established diagnosis of HCM

Exclusion criteria

• Known history of coronary or peripheral artery disease
• History of myocardial infarction
• Pregnant or lactating females
• Hypersensitivity to any ultrasound contrast agent
• Evidence right-to-left or bi-directional intracardiac shunt
• Moderate or greater valve disease other than from HCM (systolic anterior motion of the mitral valve)
• History of septal ablation or myectomy
• Hemodynamic instability
• Pacemaker dependent heart rhythm

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Patients with HCM

Experimental group

Description:

This is a prospective, non-blinded single center study. Subjects with known HCM with variant will be recruited. MCE at rest and during vasodilator stress will be performed. Full echocardiography including for diastolic function and regional strain imaging will also be performed. Patient history and questionnaires will be used for evaluation of symptoms and arrhythmias.

Treatment:

Drug: Echo and myocardial contrast echocardiography perfusion imaging