Peri-appendiceal Abscess and Phlegmon in Acute Complicated Appendicitis Patients

Fudan University

Status: Not yet enrolling

Conditions: Acute Complicated Appendicitis With Peri-appendiceal Abscess or Phlegmon

Treatments: Other: Clinical data collection

Study type: Observational

Funder types: Other

Identifiers

NCT06490185

Zhongshan-HHY-06

Details and patient eligibility

About

This study aim to analyze the clinical data of patients who underwent emergency appendectomy for acute complicated appendicitis with peri-appendiceal abscess or phlegmon, identify factors influencing the post-operative length of hospital stay (LOS), and improve treatment strategies.

Full description

Appendicitis is defined as inflammation of the vermiform appendix and worldwide is the most common reason for emergency abdominal surgery. Globally, the annual incidence is 96.5 to 100 cases per 100 000 adult population. For acute uncomplicated appendicitis, antibiotic therapy has emerged as the primary treatment, often allowing patients to avoid surgery. However, the management of acute complicated appendicitis requires careful consideration of various treatment options.

Complicated appendicitis, characterized by peri-appendiceal phlegmon or abscess formation, presents additional challenges and often requires a more comprehensive treatment approach. Management strategies have evolved to incorporate both conservative and surgical treatments, tailored to the patient's condition. Typically, for early-stage appendicitis (duration of symptoms ≤72 hours) with peri-appendiceal phlegmon, surgical treatment is recommended, while late-stage appendicitis (duration of symptoms >72 hours) or cases with peri-appendiceal abscess formation are initially managed conservatively with percutaneous drainage and antibiotics. Despite this, some patients still prefer surgical intervention for various reasons. Currently, there is a lack of studies on the outcomes of patients with acute complicated appendicitis who opt for surgery over conservative treatment, highlighting the need for further research.

In practical terms, the benefits and risks of all treatment options should be thoroughly presented and discussed. Recommendations for surgery versus a conservative treatment-first approach should be based on individual clinical and radiographic findings, as well as patient treatment expectations and preferences. This study aim to investigate the clinical significance of peri-appendiceal abscess or phlegmon in the surgical management of acute complicated appendicitis.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who were aged ≥18 years, Patients who were clinically diagnosed with acute appendicitis, Patients who had a peri-appendiceal abscess or phlegmon on CT scan, Patients who opted to undergo immediate emergency surgery as their primary choice, Patients who refused conservative treatment first (antibiotic therapy and ultrasound/CT-guided drainage).

Exclusion criteria

• Patients younger than 18 years, Patients have a history of prior malignancies, Patients with diffuse peritonitis, Patients with incomplete clinical or pathological records.