Peri Kasai Portoenterostomy Anchoring of the Jejunal Loop

Tanta University

Status: Enrolling

Conditions: Biliary Atresia

Treatments: Procedure: kasai portoenterostomy

Study type: Interventional

Funder types: Other

Identifiers

NCT04961034

33943/7/20

Details and patient eligibility

About

the study of the effect o the hanging of the jejunal loop to the peri KPE Glisson capsule on the rate of bile drainage and requirement of liver transplantation

Full description

To evaluate the effect of anchoring jejunal loop to Glisson capsule of liver after completion of modified Kasai portoenterostomy (KPE) on the frequency of attacks of cholangitis and the overall incidence of native liver survival.

Methods: Retrospective study included 29 infants diagnosed as biliary atresia (BA). They were subjected to modified KPE. Two subgroups were present. Group A included 16 infants and had KPE. Group B included 13 infants and had the assumed modification. Wider dissection of fibrous portal plate was considered in both groups. After completion of KPE, the jejunal loop anchored to Glisson capsule of liver at porta hepatis in group B.

Enrollment: 26 estimated patients

Sex: All

Ages: 4 to 8 weeks old

Volunteers: No Healthy Volunteers

Inclusion criteria

• infants with biliary atresia diagnosed and treated before 60th day of age

Exclusion criteria

• infants older than 60 days

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Sequential Assignment

Masking: None (Open label)

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26 participants in 2 patient groups

classic KPE

Other group

Description:

the classic management of biliary atresia as described

Treatment:

Procedure: kasai portoenterostomy

modified KPE

Other group

Description:

we added 2 sutures posterior, one on each side and two anterior. this will hang the jejunal loop to promote tension free anastomosis

Treatment:

Procedure: kasai portoenterostomy