Peri-operative Vitamin D Therapy for Hepatectomy

National Taiwan University

Status: Not yet enrolling

Conditions: Perioperative Complication; Vitamin D Deficiency; Hepatocellular Carcinoma

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Vitamin D

Study type: Interventional

Funder types: Other

Identifiers

NCT05650151

202209057RINA

2022-11-007A (Other Identifier)

Details and patient eligibility

About

The goal of this double-blind, randomized controlled trial is to test the effect of short-term and high-dose vitamin D therapy in patients undergoing hepatectomy for hepatocellular carcinoma.

Full description

Participants will receive short-term high dose of vitamin D during perioperative period.

The main questions the study aims to answer are:

1. If vitamin D therapy benefits perioperative care
2. If short-term high dose of vitamin D supplement is safe

Enrollment: 200 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients older than 20 years
• Patients will undergo hepatectomy for hepatocellular carcinoma.

Exclusion criteria

• Patients with hypercalcemia, hyperparathyroidism, sarcoidosis, multiple myeloma

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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200 participants in 2 patient groups, including a placebo group

Vitamin D group

Experimental group

Treatment:

Dietary Supplement: Vitamin D

Control group

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo