Peri-Transfusion QOL Assessments (PTQA): A New Paradigm of Transfusion Decision Support for Patients With MDS

Dana-Farber Cancer Institute

Status: Completed

Conditions: Myelodysplastic Syndromes

Treatments: Other: Peri-Transfusion QOL Assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT03660228

18-307

Details and patient eligibility

About

This research study is evaluating how to best tailor blood transfusion decisions to match the quality of life changes experienced by individual patients with MDS.

Full description

Each patient with MDS reacts differently to blood transfusions; some will feel better after transfusion, while others may not. The main purpose of this survey study is to determine whether it is possible to use quality of life changes - as measured by a validated questionnaire - experienced by individual patients to help physicians and patients with MDS make decisions regarding future blood transfusions. This research is being done because the investigators hope to help doctors better understand the impact of blood transfusions on the quality of life of each patient.

The study uses a standardized MDS-specific quality of life questionnaire that participants will fill out before and after an upcoming transfusion. The investigators will compare the scores of these questionnaires and notify both the participant and provider if the participant has experienced any changes (positive or negative) in his/her quality of life before and after transfusion. The investigators' hope is that doctor-patient teams will use this quality of life information to determine whether the participant should continue receiving transfusions, decrease the frequency of transfusions, or stop receiving transfusions altogether if not needed.

Enrollment: 62 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years of age
• Patients with MDS
• Patients approaching an Hb of 8.5 g/dL during enrollment period OR
• Patients with >1 transfusion scheduled during an 8-week period
• Ability to read and understand English

Exclusion criteria

• Age <18 years
• Cr > 2
• Known CHF
• Unstable Angina
• Hb level below 7.5 g/dL or above 8.5 g/dL
• No plan for future transfusion.
• Patient enrollment will happen after patient has consented and scheduled their first/next transfusion.
• Patient will not be enrolled if no future transfusions are scheduled.

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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62 participants in 1 patient group

Peri-Transfusion QOL Assessment

Experimental group

Description:

* Participants will be given a study packet containing a paper copy of the QUALMS * Study participants will fill out the survey on the day before their first/next pRBC transfusion. * Study participants will receive a second paper copy of the QUALMS, along with a stamped envelope addressed to the appropriate site * The second assessment will be scored and compared with the first, and both the patient and provider will be sent a report with the results

Treatment:

Other: Peri-Transfusion QOL Assessment