Pericapsular Nerve Group Block for Elective Hip Arthroplasty

Centre Hospitalier Universitaire de Tivoli

Status: Unknown

Conditions: Postoperative Pain

Treatments: Procedure: PENG Block with 0,9% saline; Procedure: PENG Block with local anesthetic

Study type: Interventional

Funder types: Other

Identifiers

NCT04231123

2019-001956-21 (EudraCT Number)

P2019/482

Details and patient eligibility

About

This study examine the effect of Pericapsular Nerve Group (PENG) Block on analgesia after elective hip arthroplasty. Half of participants will receive a PENG Block with local anesthetic, while the other half will receive a PENG Block with a placebo.

Full description

Optimized analgesia is crucial for early mobilization after hip arthroplasty. Regional anesthesia, like fascia iliaca block or femoral nerve block, have limited indication because of motor blockade whereas local infiltrations analgesia have shown conflicting analgesic efficacy results in hip arthroplasty.

Pericapsular nerve group (PENG) block is a new regional anesthesia technique targeting specifically sensory nerve branches of the hip articulation. It has been originally described in hip fracture patients.

The aim of this study is to evaluate the efficacy of PENG block on analgesia after elective hip arthroplasty.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective total hip arthroplasty
• General anesthesia
• Enhanced Recovery Program

Exclusion criteria

• American Society of Anesthesiologists (ASA) Score > 2
• Drug allergy
• Significant psychiatric disturbances
• Preoperative opioid use
• Contraindication to acetaminophen, celecoxib, methylprednisolone or tranexamic acid
• Body Mass Index > 40 kg/m²

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups, including a placebo group

PENG group

Experimental group

Description:

PENG block with 20 ml of a mixture of 1% Lidocaine with 0,5% Ropivacaine and 1/400.000 Epinephrine

Treatment:

Procedure: PENG Block with local anesthetic

Placebo group

Placebo Comparator group

Description:

PENG block with 20 ml of 0,9% saline

Treatment:

Procedure: PENG Block with 0,9% saline