Perichondrium Autograft in Refractory Necrotizing Scleritis (PCRNS)

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Status: Completed

Conditions: Necrotizing Scleritis

Treatments: Procedure: Perichondrium Autografts

Study type: Interventional

Funder types: Other

Identifiers

NCT02864823

PCRNS-1

Details and patient eligibility

About

Necrotizing scleritis with severe ischemia is refractory to conventional treatment because of avascular necrosis.

The investigators assessed the therapeutic efficacy and safety of autologous perichondrium transplantation in patients with severe ischemic necrotizing scleritis, and analyzed the therapeutic effects.

Full description

Ischemic necrotizing scleritis patients who showed persistent and progressive scleral melting were included in this study.

Perichondrium tissue was harvested from the patient's ear cartilage and transplanted to reconstruct the scleral defect after the necrotic tissue removal.

Enrollment: 20 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. impending perforation or perforation state of sclera;
2. graft melting following previous surgery;
3. bacterial or fungal infection of sclera or graft after previous surgery;
4. discomfort due to protrusion of scleral calcification with ischemic necrosis
5. broad avascular area larger than 10 mm in diameter

Exclusion criteria

1. asymptomatic patients
2. smaller scleral defect less than 10 mm in diameter
3. shallow scleral defect

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

20 participants in 1 patient group

Perichondrium

Experimental group

Description:

Perichondrium Autografts

Treatment:

Procedure: Perichondrium Autografts