Periinterventional Outcome Study in the Elderly (POSE)

Mark Coburn

Status: Completed

Conditions: Mortality; Complication, Postoperative

Treatments: Procedure: Surgical or non-surgical intervention

Study type: Observational

Funder types: Other

Identifiers

NCT03152734

17-070

Details and patient eligibility

About

The POSE study will predict critical stages and outcome in a large sample of all surgical and non-surgical interventional patients ≥80 years of age in Europe.

Full description

Elderly population (≥80 years) will increase from 5.3% of the total population in 2015 to 9% in 2040. This implies an increasing number and variety of surgical and non-surgical interventional procedures. Little is known about the in-hospital mortality rates in the overall elderly interventional population. Compared with younger interventional patients, the elderly are at greater risk of peri-interventional mortality and morbidity, because of decline in physiological and cognitive reserve, and frequent comorbidities. Previous data are mostly limited to specific populations, like the elderly hip fracture patient.

The investigators aim to recruit as many as possible centers throughout Europe, to participate in this study. A total sample size of 7500 patients will provide reasonable and valid results for the study aims. The primary endpoint will be analysed by fitting a COX-Regression model to the data of the post-interventional mortality until day 30.

Enrollment: 9,500 patients

Sex: All

Ages: 80+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 80 years
• Written informed consent according to the national law requirements
• All consecutive patients undergoing surgical and non-surgical interventions (e.g. radiological, neuroradiological, cardiological, gastroenterological) with anaesthesia care (done by an anaesthetist) within the selected inclusion period of four weeks
• Elective and emergency procedures
• In-patient and out-patient procedures

Exclusion criteria

• People who are institutionalized by court or administrative order
• Patients with re-intervention within the 4 week period, who were already enrolled in this study

Trial design

9,500 participants in 1 patient group

Elderly patient

Description:

Elderly patient undergoing surgical and non-surgical intervention with the use of anesthesia provided by an anesthetist

Treatment:

Procedure: Surgical or non-surgical intervention