Perinatal Outcome After Premature Rupture of Membranes

Saint Thomas Hospital (HST)

Status: Completed

Conditions: Premature Rupture; Fetal Membranes

Study type: Observational

Funder types: Other

Identifiers

NCT01538030

MHST2012-03

Details and patient eligibility

About

Premature rupture of membranes is an important cause of neonatal morbidity and mortality, mainly because of the complications associated with this pathology (oligohydramnios, cord compression or prolapse, infection). When rupture of the membranes occur the risk of cord compression increases but there is little evidence regarding this complication and amniotic fluid volume. The investigator's focus are the perinatal outcomes according to amniotic fluid volume (< 5 or >5).

Enrollment: 80 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Gestational age between 24-34 weeks.
• Confirmed diagnosis of premature rupture of membranes.

Exclusion criteria

• Twin pregnancies.
• Obstetric pathologies that require immediate termination of pregnancy (severe preeclampsia, abruptio placenta, cord prolapse).
• Termination of pregnancy (whatever the reason) before complete corticoid treatment.
• Incomplete recollection of all data required for analysis.

Trial design

80 participants in 2 patient groups

Amniotic Fluid Volume > 5

Description:

Pregnant patients with gestations between 24-34 weeks with premature rupture of membranes that, when the decision was made to interrupt the pregnancy, had amniotic fluid volume index above 5.1

Amniotic Fluid Volume < 5

Description:

Pregnant patients with gestations between 24-34 weeks with premature rupture of membranes that, when the decision was made to interrupt the pregnancy, had amniotic fluid volume index of 5 or less.