Perinatal Outcomes in Patients With Elevated sFlt-1/PlGF Ratio

Saint Thomas Hospital (HST)

Status: Completed

Conditions: Hypertension in Pregnancy

Treatments: Diagnostic Test: Standard of care

Study type: Observational

Funder types: Other

Identifiers

NCT06403722

2023-631

Details and patient eligibility

About

Retrospective cohort study that evaluated 190 subjects admitted with diagnosis of hypertensive disorder of pregnancy, between 24 and 36 6/7 weeks, with an sFlt-1/PlGF index greater than or equal to 110. Data were collected on their clinical course prior to termination of pregnancy, using the last reported sFlt-1/PlGF ratio value to classify the population into four cohorts: values between 110-205, between 206 and 654, between 655 and 999 and greater than 1000.

Enrollment: 190 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of hypertensive disorder of pregnancy
• Gestational age between 24 - 36 6/7
• sFlt-1/PlGF > 110

Exclusion criteria

• Gestational age below 23 6/7 weeks and above 37 weeks at the moment of admission.
• Absence of sFLt-1/PlGF ratio result.

Trial design

190 participants in 4 patient groups

sFlt-1/PlGF: 110-205

Description:

Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF between 110-205.

Treatment:

Diagnostic Test: Standard of care

sFlt-1/PlGF: 206-654

Description:

Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF between 206-654.

Treatment:

Diagnostic Test: Standard of care

sFlt-1/PlGF: 655-999

Description:

Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF between 655-999.

Treatment:

Diagnostic Test: Standard of care

sFlt-1/PlGF > 1000

Description:

Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF above 1000.

Treatment:

Diagnostic Test: Standard of care