PERINE : Effect of Prenatal Exposure to Neurotoxicants on the Developing Brain : an MRI Study

Rennes University Hospital

Status: Completed

Conditions: Effects of Neurotoxicants on the Brain

Treatments: Other: neuropsychological assessment; Device: MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT02125110

2013-A01420-45

Details and patient eligibility

About

This project aims at evaluating the consequences of prenatal exposure to neurotoxicants (solvents, organophosphate pesticides) on the developing brain, in children aged from 10 to 12 years.

Enrollment: 112 patients

Sex: All

Ages: 10 to 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children included in the cohort PELAGIE
• Children participated in the study PEPSY
• Age between 10 and 12 years (pilot study)

Exclusion criteria

• Maternal smoking and or alcohol consumption during pregnancy (study group)
• Children with a health event affecting neurodevelopment
• Children treated with methylphenidate, psychotropic or anti-epileptics

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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112 participants in 2 patient groups

study group (cohort PELAGIE)

Experimental group

Description:

100 children included in the cohort PELAGIE

Treatment:

Device: MRI

Other: neuropsychological assessment

pilot group (no cohort PELAGIE)

Experimental group

Description:

10 children not included in the PELAGIE cohort to optimise MRI

Treatment:

Device: MRI